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Physical and Pharmacological Effects of Marijuana



Cannabis isn’t just the most abused illicit drug in the United States (Gold, Frost-Pineda, & Jacobs, 2004; NIDA, 2010) it’s in fact the most abused illegal drug worldwide (UNODC, 2010). In the United States it’s a schedule-I substance which means that it is officially regarded as having no medical use and it is highly addictive (US DEA, 2010). Doweiko (2009) explains that not all of cannabis has abuse potential. He therefore suggests utilizing the common terminology marijuana when referring to cannabis with abuse potential. For the sake of clarity that this language is employed in this paper also.
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Today, marijuana is in the forefront of global controversy debating the appropriateness of its prevalent illegal status. In many Union states it has become legalized for medical purposes. This trend is called “medical marijuana” and can be strongly applauded by advocates while simultaneously loathed aggressively by rivals (Dubner, 2007; Nakay, 2007; Van Tuyl, 2007). It is in this context that it had been decided to pick the subject of the physical and pharmacological effects of marijuana to the cornerstone of the research article.

What’s marijuana?

Marijuana is a plant more correctly referred to as cannabis sativa. As stated, some cannabis sativa plants don’t have abuse potential and are known as hemp. Hemp is used widely for various fiber products such as newspaper and artist’s canvas. Cannabis sativa with abuse potential is that which we call marijuana (Doweiko, 2009). It’s interesting to note that although widely studies for many years, there is a lot that researchers still do not know about marijuana. Neuroscientists and biologists understand exactly what the consequences of marijuana are but they still do not fully understand why (Hazelden, 2005).

Deweiko (2009), Gold, Frost-Pineda, & Jacobs (2004) point out that of about four hundred known compounds found in the cannabis plants, researchers know of over sixty that are thought to possess carcinogenic effects on the human brain. The most well known and potent of these is â??-9-tetrahydrocannabinol, or THC. Like Hazelden (2005), Deweiko states that while we know many of the neurophysical effects of THC, the motives THC produces these effects are uncertain.




As a carcinogenic chemical, THC directly impacts the central nervous system (CNS). It impacts a enormous range of neurotransmitters and catalyzes other biochemical and enzymatic activity as well. The CNS is stimulated while the THC activates specific neuroreceptors in the brain causing the various physical and emotional reactions which are going to be expounded on more especially further on. The only substances that may activate neurotransmitters are substances that mimic chemicals that the brain produces naturally. The fact that THC stimulates brain function educates scientists that the brain has natural cannabinoid receptors. It is still unclear why people have natural cannabinoid receptors and how they work (Hazelden, 2005; Martin, 2004). What we do understand is that bud will stimulate cannabinoid receptors up to twenty times more knowingly than some of their body’s natural hormones ever could (Doweiko, 2009).

Perhaps the biggest puzzle of all is that the relationship between THC and the neurotransmitter serotonin. Serotonin receptors are among the most stimulated by all psychoactive drugs, but most specifically alcohol and nicotine. Independent of bud’s connection with the chemical, serotonin is already a modest understood neurochemical and its supposed neuroscientific roles of function and functioning are still largely hypothetical (Schuckit & Tapert, 2004). What neuroscientists have discovered definitively is that marijuana smokers have very substantial levels of dopamine action (Hazelden, 2005). I would hypothesize that it may be this relationship between THC and serotonin that explains the “marijuana maintenance program” of attaining abstinence from alcohol also enables marijuana smokers to avoid painful withdrawal symptoms and avoid cravings from alcohol. The efficacy of “marijuana maintenance” for helping alcohol abstinence is not scientific but is still a phenomenon I have personally witnessed with many clients.

Interestingly, marijuana mimics a lot of neurological responses of other drugs that it is very difficult to classify in a certain class. Researchers will place it in one or more of these classes: psychedelic; hallucinogen; or serotonin inhibitor. It has properties that mimic similar chemical responses as opioids. Other chemical reactions mimic stimulants (Ashton, 2001; Gold, Frost-Pineda, & Jacobs, 2004). Hazelden (2005) classifies marijuana in its own special class – cannabinoids. The reason for this confusion is that the intricacy of the many psychoactive properties found within bud, both known and unknown. One recent customer I saw could not recover from the visual distortions he suffered as a consequence of pervasive psychedelic usage as long as he was still smoking marijuana. This seemed to be as a consequence of the psychedelic properties found in busy cannabis (Ashton, 2001). Although not strong enough to produce these visual distortions by itself, marijuana was powerful enough to stop the brain from healing and recovering.


Cannibinoid receptors can be found throughout the brain thus affecting a huge array of functioning. The most important on the emotional level is the stimulation of the brain’s nucleus accumbens perverting the brain’s natural reward facilities. Another is the fact that of the amygdala which controls one’s emotions and anxieties (Adolphs, Trane, Damasio, & Damaslio, 1995; Van Tuyl, 2007).

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Semi Mount Ring

Diamond Semi Mount Ring Enables You Make Your Engagement Ceremony Quite Special


How could you ignore the significance of a ring particularly at the time when you have a plan to propose a woman? It is true that today market is flourished up with a wide assortment of rings; hence, for anyone sometimes it becomes very difficult to select the one which matches their requirements and pocket also. And, of course, your small concern in this regard can bring a gorgeous and memorable grin on the face that your fiancée.
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Nowadays, semi-mount rings are in good demand. And, in this section, people from different places of the world are demonstrating their great interest in making use of a diamond semi mount ring. This kind of stone is offered in a huge assortment of colors, designs and shapes that allows the users to approach the product that’s very closer to their own expectations.



Going with a semi-mount ring can be a cost-effective decision for anybody. These ornaments are enriched with an awareness of versatility of a colored gemstone. And, when it comes to acquiring a more sophisticated and in depth appearance, the significance of such entity can’t be ignored at any cost.

Sentiments always induce many of us choose the one which touches the heart and spirit of our fiancée. Diamond semi mount ring may be the ideal choice for everyone who really want to rock their engagement ceremony and produce their own fiancée feel happy as well. The usage of the ornament will not only allow you to maintain the custom of your family, but it will also make a significant impact in making the engagement occasion quite unique. This type of ring may also let you update your old ring and ensure it is appropriate for your worried intent. In general, diamond plated bracket has now made its unique place amongst the heart of numbers of buyers from all around the world.

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Maid Services In Mumbai

How To Get The Most Suited Maids For Your Personal Home


Maids are also called domestic workers around the home. These individuals have abilities in performing household duties around the house. The basic duties involve cleaning and cooking. It’s important to find a professional if you’re looking for a maid. Getting one that does not have all the required skills will mean added responsibilities left upon you or you’ll need to find time to teach her the way you want the duties to be performed. With the busy time deadlines and schedules in work requirements, not a lot will get the opportunity to train their aids in performing a variety of activities.
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House cleaning is one of one of the services which may prove to be a challenge to the Maids.

Instead of bothering yourself becoming one that isn’t effective, why don’t you shop around for a professional helper from businesses that have a standing in getting quality Maids. There are businesses which are running educational abilities for national employees. These offer skilled workers to all looking for professionals. The workers have to go through an education system in which they are taught how to conduct several kinds of machines at the home in addition to provide the homeowner quality cleaning services. This may vary from fabric cleaning, surface cleaning, in addition to Maids services.


You may easily receive a company which provides permanent working cleaners for households that have a demand for full time workers in addition to homes that have a demand for contract employees that report on changes. The complete time domestic employees are assigned to families that need a full time maid in the home. These often reside in the home they are assigned to. They might be given a room in the main house or receive a servant’s quarter to live in. The ones that work in shifts on the other hand involve women that have delegated days to work in a certain household. These may have basic duties to perform including laundry and arranging the home to maintain items in order. They might need to report to a single dwelling once or twice in a week on particular days.

With different sorts of employees in the current market, it’s simple to get one that will suit your requirements in addition to your budget. It’s true that the prices for these domestic employees have risen up. There however are companies which have trained staff at great rates. To access this, you need to go at your own pace and produce a fantastic search over the internet to identify a company that will provide what you require.

Specifying the type of responsibilities that the maid will be required to perform in the home only makes it easier for the enterprise to assign you the perfect candidate for the job. They have knowledge about the abilities of the Maids thus understand who will best fit your requirements. Obtaining a maid from such companies helps you acquire honest and trust worthy workers. The company is going to track the progress of the maid thus ensuring that you get what you are paying for.

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Gold Mosaic

Jinyuan mosaic products introduction

We Boluo Jinyuan Mosaic Co.,Ltd. have major mosaic items as below.


1.Mosaic Pattern:

Mosaic pattern maybe a much better calls is Pixel mosaic which make in mould.We have thousands of design of the, the majority of them are out of our Jinyuan mosaic designer’s thought,so keep original. By the way,the material and colour we both could be customized needs,various sorts of mosaic tile -vitreous glass mosaic,crystal mosaic.,foil glass mosaic,golden line mosaic,iridescent glass mosaic,coloured gold mosaic

…to get choosing.Also difference colour

-red,orange,yellow,green,blue,purple,magenta,rose,white,black,grey,golden,silver…in gap tone also.It is becoming the most significant home wall decorative material in world.

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2.Mosaic Mural:

Mosaic mural is a luxury artwork for wall,ceiling or many others permanent surface.We have a set of specialist mosaic mural designers that can create unique styles of mosaic design works such as Arabic-style mosaic, American-style mosaic, European fashion mosaic cut, Southeast Asian style,Austria design… … mosaic mural, mosaic mural utilize ice jade mosaic or crystal mosaic or foil glass mosaic as raw material, design with individuals, scenery, animals,building or any pictures ,even your own photos. If dimension complex not as ordinary rectangle or square,pls provide correct measurements for drawing make.After verified, then we produce around 12-15 days.


3.Gold mosaic:

Our gold mosaic is make by transparent glass with imitation gold foil (Leaf) mounted underside.The edge is our gold mosaic tile can use in warm water and outside.We utilize Ag+ foil with epoxy resin solid bottom protect,so it can be waterproof, anti oxygen, andalkali resistance also not easy to fade. Incidentally,we’ve got SGS evaluation report and patent certification of this and a few photos of successful projects that can give customers confidence to purchasing.

Our measure will not stop,many produce and worth mosaic tiles will confront to advertise after carefully test, our customers are mosaic wholesale, mosaic store, construction team,trading firm,design hub and private client … …welcome contact us – Jinyuan mosaic for long time collaboration establish. Every sequence, we hundred per cent focus!

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Belgrade Apartments

Belgrade Features the Best Hotel


Do you want a perfect resort? Belgrade will give you an chance to stay in one of the world’s most beautiful resorts. The most lavish Moscow hotel represents a palace, where everyone can feel like a king.

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Moscow is the most beautiful resort in Belgrade.

At the beginning of last century, a brand new hotel was opened in the capital of Serbia. Solemn music welcomed thousands of guests. All major newspapers wrote about this occasion. A brand new hotel was known as Moscow. Soon, it became one of Belgrade city sights and a favorite meeting place for young businessmen. Having stepped on the Serbian land, foreigners from all around the world wanted to have a cup of java in the Moscow resort. This resort became the symbol of this city.

Central hotel in Belgrade.

Moscow hotel is located in the center of the city, only a few steps from renowned Prince Michael street. It offers hundreds of interesting and luxury stores, galleries, shopping malls and restaurants. The hotel is close to the theater, famous fountains and Kalemegdan Fortress. Moscow is one of the most recognizable hotels in the city. This hotel is popular both among neighborhood residents and travelers wanting to enjoy a stay at one of their most comfortable hotels in Europe. Designed for European guests, Moscow is the only hotel that has no flat number 13.


Luxury hotel in Belgrade.

Moscow hotel is a sign of the nineteenth century luxury. Each detail is created to cause admiration: a luxurious lounge with magnificent end, staircase decorated with expensive wood, rooms with classic furniture and interior design performed in sumptuous Art Nouveau design. This hotel was made for people who appreciate beauty and exquisite combination of contemporary comfort and noble style of Serbia. The hotel building was created by Serbian architect Jovan Ilkich in cooperation with Russian architects out of St. Petersburg. Thanks to perfect collaboration of brilliant architects, this hotel still includes boldness and beauty of architectural solutions. Russia insurance group encouraged construction of this resort. In the dawn of the previous century, “modern” style was quite common. Architecture of Moscow resort is done in palace style. It is just as luxurious both outside and indoors. The facade is faced with ceramic, marble, highly glazed pottery and adorned with mosaics and stained glass. Many details of the facade and interior decoration were created in Hungary in the planet’s famous Zholnay factory. Moskow resort is among those European landmark buildings of the early 20th century.

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Belgrade Apartments

The Main Reasons People Visit Belgrade


The city of Belgrade is known for its cultural and historical sites, which are intrinsic to the city’s planning and heritage. Some of these cultural attractions talk about Belgrade’s past, while some talk about its resilience to war and dangers. Most importantly, all these tourist places acquaint the tourists with Belgrade and its journey towards becoming one of Europe’s most important capital cities.

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1. Belgrade Fortress

Situated beside the scenic Danube and Sava rivers, the Kalmegdan Park and the Belgrade Fortress form one of the most important cultural monuments in Belgrade. This is the epicenter for nearly all significant cultural and sports events in the city. This Fortress is considered to be the city’s endless supply of joy and represents strength, resilience and solitude.

2. The Skadarlija

The Skadarlija can be called the Old Bohemian quarter of Belgrade. It was built way back in the late 19th century and its own restaurants and taverns were the meeting places of several famous cultural personalities of these times. This area is sure to enchant you with its white cobblestone, linden trees along with the yummy smell of Serbian cuisine. Remember to go to some of the renowned café restaurants of Skadarlija such as, Tri sesira, Dva bela goluba, Dva jelena etc..

3. Republic Square

Republic Square is the most favorite so-called hangout spot for the young people of Belgrade. You may use this as a meeting place for friends or as a place to just walk around. For many who do not understand Belgrade that well, the Republic Square is frequently the starting point for an excursion.

4. The Millenary Monument

This brick and stone monument provides an wonderful view of Gardos Hill. The design of the tower combines various elements with romantic trends predominating. The Monument provides tourists with a bird’s-eye view of town centre and which will have a therapeutic impact on most. Added to that, the church bells offer you another element of calmness and tranquility into the location. The Monument can be a place of various cultural activities.

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Company Formation in Dubai

Dubai Expo – a Once in a Lifetime Opportunity to Boom your Business


Dubai Expo – a Once in a Lifetime Opportunity to Boom your Business

Dubai Expo 2020 is just 3 years away and companies across the world are rushing towards Dubai to reap the benefits of this global event. There has been a record result in the number of licenses issued and renewed in 2017 in Dubai alone. This emphasizes the rapid growth and competitiveness of the Business terrain in Dubai and UAE. With Expo 2020, contracts worth AED 5 billion will be allotted to local and international Small and Medium Enterprises. Apart from this, more than 70 million visitors are expected to come to Dubai leading up to the event as per government sources and business can benefit hugely from this already fertile and ever-growing market. A senior business consultant who works for one of the ‘big four’ consulting firms categorically stated that “this is the right time for new businesses to set up their companies in Dubai and you can get just enough time to understand and analyze the market and launch yourself into this ocean of opportunities.”

For many years, global businesses have had a misplaced notion that starting a business in Dubai is costly and time-consuming. But the Dubai Department of Economic Development (DED), has come up with some truly robust processes to assure that this is a myth and have dispelled this dated notion with issuing licenses to set up business in Dubai in as little as one day. Mr. Midhun Vikraman, CEO of BizVest, a Business Consulting company that helps clients with Company Formation, Business Incorporation, and Business Advisory services in the UAE said that SMEs and entrepreneurs are seeking help from traditional company registration service providers to set their businesses in the UAE. These traditional companies are not aware of the recent developments in company formation and licensing procedures across Free Zones, Mainland and Offshore, nor are they equipped to take advantage of the latest digital services offered by the various UAE jurisdictions. For example, the Business Registration and Licensing (BRL) of DED has launched e-services that among many things offer ‘instant license’ where a client can get a commercial license in as little as 5 minutes, that too without a legal contract or trade name or rent contract. So it is highly important that SMEs should approach and engage with the right business incorporation partner to set up their company in the UAE.


BizVest can provide you specific advice on the perfect business set up, what type of company you need to register in Dubai, based on the type of business you undertake. BizVest also provides professional insights on the specific benefits of setting up a company in Free Zone, Mainland or Offshore and the type of licensing that best fits a particular business. As a special package, BizVestis now offering FREE “Pick n’ Choose’ services ranging from Website development, Social Media Marketing, Search Engine Optimization and Brand Identity for new licensees. BizVestcan surprise prospective clients with incredibly low waiting time and exceptional quality of services…all for the least amount of money. With BizVest, starting a business in Dubai is now cheap, quick and easy.

For comprehensive information on starting a business in the UAE, Bizvesthas a dedicated Resources page that guides its users step by step on all the updates, process and benefits. TheResources pages are carefully designed to guide users through Company Formation, Freezone, Offshore, Expo 2020 and much more.

Company Formation:

Freezone Company Formation:

Offshore Company Formation:

Expo 2020:

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